Automédication et conseil pharmaceutique en période de pandémie de COVID-19 à Oran / Self-medication and pharmaceutical advice during the COVID-19 pandemic in Oran

Introduction : L'épidémie de Covid-19 a créé une psychose et une anxiété généralisées. Cela pourrait être lié, d'une part, à la mortalité élevée observée dans le monde, et d'autre part, à l'absence d'une thérapie spécifique. Face à cette situation, de nombreuses substances ont été utilisées sans avis médical. L'objectif de cette étude était d'évaluer les pratiques de l'automédication en situation de Covid-19 à Oran. Matériel et méthodes : Il s'agit d'une enquête transversale observationnelle réalisée par questionnaire électronique anonyme (googleforms) et distribué, par e-mail, à des pharmaciens adhérents à la section ordinale régionale des pharmaciens d'Oran. Les réponses ont été analysées par le logiciel Statistical Package for the Social Sciences (SPSS). Résultats : Au total, 69 réponses ont été obtenues. La proportion de pharmaciens ayant perçu une tendance à la hausse de l'automédication était de 58,0%. Environ le quart des pharmaciens (22,9%) avaient constaté une augmentation de l'automédication à l'hydroxychloroquine ; néanmoins, aucune toxicité secondaire à l'usage de ce médicament n'a été observée. En cette situation d'épidémie de Covid-19, 91.3% de l'échantillon d'étude avaient constaté une augmentation du recours aux vitamines et compléments alimentaires, avec une consommation fréquente de la vitamine C à 1gr/j ainsi que d'autres complexes vitaminiques à base de vitamine D, vitamine B9 et fer chez la femme enceinte ou allaitante. Conclusion : Notre étude a montré qu'en période de Covid - 19 la tendance à l'automédication a augmenté. L'automédication à l'hydroxychloroquine a été observée durant cette pandémie néanmoins l'usage d'autres substances telles que les vitamines et les compléments alimentaires était plus fréquent.

Introduction : the epidemic of Covid-19 has created generalized psychosis and anxiety. This could be linked, on the one hand to the high mortality observed in the word, and the other hand to the absence of specific therapy. Faced with this situation, many substances have been used without medical advice. The objective of this study was to evaluate the practice of self-medication in COVID-19 situation in Oran. Materials and methods : this is an observational cross sectional survey carried out by an anonymous electronic questionnaire and distributed, by email, to pharmacist belonging to the regional ordinal section of pharmacist in Oran. The answers were analysed by the software Statistical Package for the Social Sciences (SPSS). Results : A total of 69 responses were obtained. The proportion of pharmacists who noticed an increasing trend in self-medication was 58,0%. About a quarter of pharmacist had observed an increase in selfmedication with hydroxychloroquin, at least no toxicity secondary to the use of this drug was observed. In this COVID19 epidemic situation, 91.3% of the study sample noted an increase in the use of vitamins and food supplements with frequent consumption of vitamin C at 1g/day as well as other vitamin comlexes based on vitamin D, vitamin B9 and iron for pregnant or breastfeeding women. Conclusion : Our study showed that during COVID-19 the tendency to self-medication increased. Self-medication with hydroxychloroquin was observed during this pandemic, although the use of other substances such as vitamins and food supplements was more frequent.

Phenolics Compounds and Biological Activity of Leaves of Anabasis Articulata, ‎an Algerian Medicinal Plant

Anabasis articulata is a Saharan plant used by Algerian traditional medicine practitioners for medicinalpurposes. The objective of this study was to investigate the antioxidant properties of the extract and fractions ofthe leaves of A. articulata. The phenolic compounds were also quantified in this plant. Anabasis articulata wasexamined for antibacterial activities of its methanolic extract using disc diffusion method. The bacteria testedinclude Pseudomonas aeruginosa ATCC 14028, Salmonella typhimurium ATCC 9027 and Bacillus subtilisspizizenii ATCC 6633. The results showed that methanolic extract exhibits a higher level of phenolic compounds(230.000±0,415) as compared to all other extracts. The FRAP test revealed that the methanolic extract has ahigher reducing power (0.1 mg / ml) compared to other extracts. IC50 (DPPH) was ranged from 3.200±0.088 to4.900 ± 0.130. The compounds quantified by HPLC in the crude extract and fractions were quercetin andascorbic acid. The results obtained indicated that A. articulata exhibits a good potential to prevent diseases andit might also be used as a natural preservative for food or cosmetic products.